GEO series
Single Cell RNA Seq of Mouse Retina from AAV-overexpressed IFN-beta and Control
GSE314326
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/04/01
GPL24247
Summary
Type-I IFNs have been implicated in the development and progression of retinal disease, however the concequence of long term ocular exposure to Type-I IFN and the cell types that are impacted has not been characterized. This study uses AAV2 to overexpress IFN-beta to achieve prolonged retinal exposure with a single intravitreal injection. We have then employed a single cell RNA sequencing approach using 10x Genomics scRNAseq examine the retinal cell types responsive to Type-I IFN.
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Paper (PMID 41760600) ↗
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