Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post- Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest
Single-nucleus RNA-seq · human · 12 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Dono vs 3 × AF vs 3 × HTK vs 3 × CanrenoneGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic ArrestJournal of the American Heart Association · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE315225_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1395367 and SRA study SRP658812. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9423254 Donor1 Dono
- GSM9423255 Donor2 Dono
- GSM9423256 Donor3 Dono
- GSM9423257 AF1 AF
- GSM9423258 AF2 AF
- GSM9423259 AF3 AF
- GSM9423260 HTK1 HTK
- GSM9423261 HTK2 HTK
- GSM9423262 HTK3 HTK
- GSM9423263 Canrenone1 Canrenone
- GSM9423264 Canrenone2 Canrenone
- GSM9423265 Canrenone3 Canrenone
- GSE202698 Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats 8 samples shares mineralocorticoid, antagonism, attenuates, receptor
- GSE275128 When glucocorticoid receptor meets the mineralocorticoid receptor in human cells 80 samples shares mineralocorticoid, receptor
- GSE313106 Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias 48 samples shares arrhythmias, cardiac
- GSE304936 Glucocorticoid and mineralocorticoid receptors jointly promote vascular development in kidney organoids 9 samples shares mineralocorticoid, receptor
- GSE261124 Physical Phase Transition of Mineralocorticoid Receptors Determines Preservation Quality of Donor Hearts for Transplantation 9 samples shares mineralocorticoid, receptor
- GSE274344 Mineralocorticoid receptor co-expression effect on ligand-induced glucocorticoid receptor interaction with the genome in human cell line 6 samples shares mineralocorticoid, receptor
- GSE281162 The Impact of PPARβ/ agonism/antagonism on human bone-marrow-derived Mesenchymal Stromal Cells 18 samples shares antagonism
- GSE270271 Rescue of Angiopoietin-2 inhibits lymphatic malformation endothelial cell proliferation through antagonism of VEGFR3 signaling 12 samples shares antagonism
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.