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Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation.

GSE317411 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/08 Platform GPL24247
Summary
Adaptive immune responses are intensely energy-dependent and rely on a local source of fuel-producing molecules which have been proposed to be derived from fat pads in which mammalian lymph nodes are embedded. However, the trigger for their release has not been identified. Here we demonstrate that cutaneous inflammation is directly correlated with rapid atrophy of perinodal fat pads and increase in embedded lymph node size. We further demonstrate that the fat pad atrophy is associated with influx of a CCR2-independent, lipid metabolising, macrophage population and that macrophage depletion ameliorates fat pad atrophy, and lymph node expansion, downstream of inflamed sites. Our data therefore identify peripheral inflammation as an antigen-independent trigger of downstream fat pad and lymph node remodelling and contributes to the release of essential nutrients to drive the energetic requirements of the adaptive immune response.
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Also filed as BioProject PRJNA1412553 and SRA study SRP665857. Searching any of these in the dataset finder brings you back here.

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