MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 12 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophyNeurobiology of disease · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317529_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1414420 and SRA study SRP658373. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 15 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9420282 70-day-old forebrain organoids, unaffected control, replicate 1
- GSM9420283 70-day-old forebrain organoids, unaffected control, replicate 2
- GSM9420284 70-day-old forebrain organoids, unaffected control, replicate 1, input
- GSM9420285 70-day-old forebrain organoids, unaffected control, replicate 2, input
- GSM9420286 70-day-old forebrain organoids, congenital myotonic dystrophy, replicate 1
- GSM9420287 70-day-old forebrain organoids, congenital myotonic dystrophy, replicate 2
- GSM9420288 70-day-old forebrain organoids, congenital myotonic dystrophy, replicate 1, input
- GSM9420289 70-day-old forebrain organoids, congenital myotonic dystrophy, replicate 2, input
- GSM9420290 70-day-old forebrain organoids, isogenic control, replicate 1
- GSM9420291 70-day-old forebrain organoids, isogenic control, replicate 2
- GSM9420292 70-day-old forebrain organoids, isogenic control, replicate 1, input
- GSM9420293 70-day-old forebrain organoids, isogenic control, replicate 2, input
- GSM9428628 80-day-old forebrain organoids, unaffected control
- GSM9428629 80-day-old forebrain organoids, congenital myotonic dystrophy
- GSM9428630 80-day-old forebrain organoids, isogenic control
- GSE288824 A Novel EBF2 Nonsense Variant Drives Adipose Tissue Fibrosis and Dysfunction in Partial Lipodystrophy Syndrome 11 samples shares dysfunction, dystrophy
- GSE311812 Immune and Repair Mechanisms Underlying Congenital Chagas 46 samples shares congenital
- GSE306440 A precision medicine approach to interpret a GATA4 genetic variant in a paediatric patient with congenital heart disease 20 samples shares congenital
- GSE285515 NKG2D blockade impairs cytotoxic CD8+ tissue resident memory T cell accumulation and attenuates severity of chronic lung allograft dysfunction after transplantation 15 samples shares dysfunction
- GSE318420 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab 210 samples shares dysfunction
- GSE313642 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab [CITE-Seq] 194 samples shares dysfunction
- GSE336982 Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction 183 samples shares dysfunction
- GSE261070 Dysfunctional neutrophil Type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization 134 samples shares dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.