Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis [RNA-Seq]
Single-cell RNA-seq · mouse · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × M0-siCON vs 3 × M0-siEHD1 vs 3 × M1-siCON vs 3 × M1-siEHD1Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate AtherosclerosisCirculation research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319027_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1421986 and SRA study SRP676098. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9508230 M0-siCON-1 M0-siCON
- GSM9508231 M0-siCON-2 M0-siCON
- GSM9508232 M0-siCON-3 M0-siCON
- GSM9508233 M0-siEHD1-1 M0-siEHD1
- GSM9508234 M0-siEHD1-2 M0-siEHD1
- GSM9508235 M0-siEHD1-3 M0-siEHD1
- GSM9508236 M1-siCON-1 M1-siCON
- GSM9508237 M1-siCON-2 M1-siCON
- GSM9508238 M1-siCON-3 M1-siCON
- GSM9508239 M1-siEHD1-1 M1-siEHD1
- GSM9508240 M1-siEHD1-2 M1-siEHD1
- GSM9508241 M1-siEHD1-3 M1-siEHD1
- GSE300299 Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice [scRNA-seq] 12 samples shares macrophage, promotes, rna-seq
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares macrophage, rna-seq
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares macrophage, promotes
- GSE325329 Transcriptomic profiling of macrophages that phagocytosed apoptotic Treg or conventional CD4⁺ T (Tconv) cells under different polarization conditions [RNA-Seq] 28 samples shares macrophage, rna-seq
- GSE237783 Complex interaction of tumor-derived factors instructs the niche specific phenotypes of tumor-associated macrophages [RNA-Seq] 28 samples shares macrophage, rna-seq
- GSE245648 The Heme-regulated transcriptional repressor, BACH1 safeguards macrophage enhancer selection, activation andtissue adaptation [RNA-seq_BMDM] 24 samples shares macrophage, rna-seq
- GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] 24 samples shares macrophage, rna-seq
- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares macrophage, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.