Irx3 ameliorates postmyocardial infarction cardiac dysfunction by regulating both inflammatory and fibrotic pathways
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × AAV9_Ctrl_Sham vs 4 × AAV9_Ctrl_MI vs 4 × AAV9_Irx3_MIGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319045_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1422016 and SRA study SRP676119. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9508642 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_Sham_1 AAV9_Ctrl_Sham
- GSM9508643 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_Sham_2 AAV9_Ctrl_Sham
- GSM9508644 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_Sham_3 AAV9_Ctrl_Sham
- GSM9508645 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_Sham_4 AAV9_Ctrl_Sham
- GSM9508646 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_MI_1 AAV9_Ctrl_MI
- GSM9508647 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_MI_2 AAV9_Ctrl_MI
- GSM9508648 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_MI_3 AAV9_Ctrl_MI
- GSM9508649 RNA-seq of mouse cardiac tissue: AAV9_Ctrl_MI_4 AAV9_Ctrl_MI
- GSM9508650 RNA-seq of mouse cardiac tissue: AAV9_Irx3_MI_1 AAV9_Irx3_MI
- GSM9508651 RNA-seq of mouse cardiac tissue: AAV9_Irx3_MI_2 AAV9_Irx3_MI
- GSM9508652 RNA-seq of mouse cardiac tissue: AAV9_Irx3_MI_3 AAV9_Irx3_MI
- GSM9508653 RNA-seq of mouse cardiac tissue: AAV9_Irx3_MI_4 AAV9_Irx3_MI
- GSE304090 Pharmacological inhibition of the epigenetic enzyme EZH2 attenuates cardiac dysfunction and mitigates lipid metabolism perturbations in a murine model of myocardial infarction 15 samples shares dysfunction, infarction, cardiac
- GSE309251 Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction 347 samples shares dysfunction, cardiac
- GSE316703 Microbiota-Derived Isovalerate Ameliorates Sex-Specific Gut Barrier Dysfunction in Malnutrition [RNA-seq colon epithelium] 50 samples shares ameliorates, dysfunction
- GSE319401 Exercise Mitigates Cardiac Dysfunction Post-MI in Ovariectomized Mice via miR-21/Sox7-Mediated Suppression of Cardiac Fibroblast Activation 24 samples shares dysfunction, cardiac
- GSE262105 Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis 21 samples shares ameliorates, cardiac
- GSE232098 Innate immune memory after brain injury drives inflammatory cardiac dysfunction 20 samples shares dysfunction, cardiac
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares dysfunction, cardiac
- GSE285475 Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction 18 samples shares dysfunction, cardiac
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.