Hereditary spastic paraplegia (HSP) gene 11 (SPG11) attenuates lipid accumulation in myeloid cells and neuroinflammation independent of α-synuclein pathology
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE324086_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1433411 and SRA study SRP681680. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run SAM24427752 … SAM24449928 and carry no group information.
- GSM9567991 SAM24427752
- GSM9567992 SAM24427753
- GSM9567993 SAM24427754
- GSM9567994 SAM24427755
- GSM9567995 SAM24427756
- GSM9567996 SAM24427757
- GSM9567997 SAM24427758
- GSM9567998 SAM24427759
- GSM9567999 SAM24427760
- GSM9568000 SAM24427761
- GSM9568001 SAM24449919
- GSM9568002 SAM24449920
- GSM9568003 SAM24449921
- GSM9568004 SAM24449922
- GSM9568005 SAM24449923
- GSM9568006 SAM24449924
- GSM9568007 SAM24449925
- GSM9568008 SAM24449926
- GSM9568009 SAM24449927
- GSM9568010 SAM24449928
- GSE279388 Inactivation of Atp7b copper transporter in the intestinal epithelial cells is associated with altered lipid processing and cell growth machinery that are independent from hepatic copper accumulation and liver histology severity 76 samples shares accumulation, independent
- GSE309404 Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation 23 samples shares accumulation, attenuates
- GSE280721 Hexokinase 2 Exacerbates Mitochondrial Damage, Neuroinflammation, and Lipid accumulation by promoting ACSL4 ISGylation in Sepsis-Associated Encephalopathy 16 samples shares neuroinflammation, accumulation
- GSE279453 Bifidobacterium lactis Derived Vesicles Attenuates Hippocampal Neuroinflammation via Targeting IL-33 to Regulate FoxO6/P53 Signaling 15 samples shares neuroinflammation, attenuates
- GSE328178 Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models 14 samples shares neuroinflammation, attenuates
- GSE304500 N,N Dimethylacetamide attenuates LPS induced neuroinflammation in a murine model 12 samples shares neuroinflammation, attenuates
- GSE304069 Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death 12 samples shares neuroinflammation, independent
- GSE288795 The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan 111 samples shares hsp
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.