← BioTransfer GEO Dataset Finder
GEO series

ZFP90 deficiency exacerbates high fat diet-induced hepatic transcriptomic remodeling.

GSE324098 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/05 Platform GPL34290
Summary
RNA-seq identified 1,038 upregulated and 263 downregulated genes (fold-change > 2) in ZFP90 KO livers compared to those in WT livers. Pathway enrichment analysis revealed that ZFP90 deficiency upregulated programs involved in immunity, inflammatory responses, and lipid metabolism-specific cytokine-cytokine receptor interactions, NF-κB, and chemokine signaling. To explore the mechanisms underlying ZFP90 deficiency-induced hepatic steatosis, we assessed hepatic gene expression based on RNA-seq data. ZFP90 deficiency increased mRNA levels of genes related to fatty acid uptake, inflammation, and fibrosis, indicating that ZFP90 loss accelerates MASLD progression through integrated inflammatory and metabolic pathways.
Published in
ZFP90 Serves as a Transcriptional Brake on NF-κB Signaling to Attenuate Diet-Induced MASLD Progression
Park S, Komatsu T, Misumi K et al. · Nutrients 2026 · PMID 42514401 · doi:10.3390/nu18142332
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE324098_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1433425 and SRA study SRP681702. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.