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Bulk RNAseq in microglia from wild-type (WT) and Lactamase B (LACTB) enymatic dead (ED) mice (LACTB S162I).

GSE324607 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/24 Platform GPL34328
Summary
Our mendelian randomization analysis showed that lower expression of LACTB in myeloid cells might be protective for Alzheimer's Disease. We evaluated how microglial cells from LACTB enzymatic dead mice show transcriptional changes.
Published in
Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer's disease risk
Goate A, Romero-Molina C, Gomez-Gutierrez R et al. · Research square 2026 · PMID 42523480 · doi:10.21203/rs.3.rs-10216155/v1
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Also filed as BioProject PRJNA1436010 and SRA study SRP683012. Searching any of these in the dataset finder brings you back here.

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