Transcriptomic profiling of lung and kidney tissues in a mouse model of severe pneumonia–associated acute kidney injury (SP-AKI)

Acute kidney injury frequently occurs in patients with severe pneumonia and contributes to poor clinical outcomes. In this study, we established a mouse model of severe pneumonia–associated acute kidney injury (SP-AKI) and performed RNA sequencing to investigate transcriptomic alterations in both lung and kidney tissues. Lung and kidney samples were collected from control mice and SP-AKI mice, followed by high-throughput RNA sequencing. Differential gene expression and pathway analyses were performed to identify molecular mechanisms involved in organ injury and inter-organ communication during SP-AKI. This dataset provides a comprehensive transcriptomic resource for understanding the molecular mechanisms underlying SP-AKI.