CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Liver, HFD, Wildtype # vs 4 × Liver, MASH, Wildtype # vs 4 × Liver, MASH, Cxcl5 KO #Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytesInternational journal of biological sciences · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE325102_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1438650 and SRA study SRP684489. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9595895 Liver, HFD, Wildtype #1 Liver, HFD, Wildtype #
- GSM9595896 Liver, HFD, Wildtype #2 Liver, HFD, Wildtype #
- GSM9595897 Liver, HFD, Wildtype #3 Liver, HFD, Wildtype #
- GSM9595898 Liver, HFD, Wildtype #4 Liver, HFD, Wildtype #
- GSM9595899 Liver, MASH, Wildtype #5 Liver, MASH, Wildtype #
- GSM9595900 Liver, MASH, Wildtype #6 Liver, MASH, Wildtype #
- GSM9595901 Liver, MASH, Wildtype #7 Liver, MASH, Wildtype #
- GSM9595902 Liver, MASH, Wildtype #8 Liver, MASH, Wildtype #
- GSM9595903 Liver, MASH, Cxcl5 KO #9 Liver, MASH, Cxcl5 KO #
- GSM9595904 Liver, MASH, Cxcl5 KO #10 Liver, MASH, Cxcl5 KO #
- GSM9595905 Liver, MASH, Cxcl5 KO #11 Liver, MASH, Cxcl5 KO #
- GSM9595910 Liver, MASH, Cxcl5 KO #12 Liver, MASH, Cxcl5 KO #
- GSE314637 RNA-seq analysis of macrophage NFATc3 or ASK1 effects on metabolic dysfunction-associated steatohepatitis 28 samples shares dysfunction-associated, steatohepatitis
- GSE304692 Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH) [RNAseq_palmitate_silencing] 24 samples shares dysfunction-associated, steatohepatitis
- GSE315019 DTMB mitigates diet-induced metabolic dysfunction-associated steatohepatitis by targeting inflammation and lipid metabolism 22 samples shares dysfunction-associated, steatohepatitis
- GSE319011 Cholesterol-rich diet exacerbates steatohepatitis in the STAM mouse model 19 samples shares steatohepatitis, exacerbates
- GSE250004 Platelet-derived thrombospondin 1 promotes immune cell liver infiltration and exacerbates diet-induced steatohepatitis. 16 samples shares steatohepatitis, exacerbates
- GSE242672 HSD17B13 Deficiency Modulates Interferon Signaling to Ameliorate Metabolic Dysfunction-Associated Steatohepatitis Fibrosis 12 samples shares dysfunction-associated, steatohepatitis
- GSE277498 Hepatoprotective effect of cinnabarinic acid in metabolic dysfunction-associated steatohepatitis 12 samples shares dysfunction-associated, steatohepatitis
- GSE328199 Limonin ameliorates metabolic dysfunction-associated steatohepatitis in mice 11 samples shares dysfunction-associated, steatohepatitis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.