GEO series

RNA-seq of mouse suprarenal aorta from VAMP8-knockout and wild-type mice with AngII or saline infusion

GSE326751 Mus musculus (mouse) RNA-seq (gene expression) 16 samples Submitted 2026/04/06 Platform GPL34290

At a glance

RNA-seq (gene expression) · mouse · 16 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 16 samples: 4 × Mouse suprarenal aorta RNA-seq, WT Saline, biol vs 4 × Mouse suprarenal aorta RNA-seq, WT AngII, biol vs 4 × Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol vs 4 × Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biolGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.

Summary (written by the submitters)

VAMP8 (vesicle-associated membrane protein 8) is a SNARE protein implicated in exocytotic secretion from immune and vascular cells. To investigate the role of VAMP8 in the vascular transcriptomic response to AngII infusion, we profiled gene expression in suprarenal aortae of VAMP8-knockout (Vamp8-/-) and wild-type C57BL/6 mice receiving 5-day continuous subcutaneous infusion of angiotensin II (AngII, 1,000 ng/kg/min) or saline via osmotic minipump.

Read the full summary ↓

Four experimental groups were generated: WT+Saline, WT+AngII, V8KO+Saline, and V8KO+AngII (n=4 per group). Differential expression analysis identified transcriptomic changes associated with AngII treatment, VAMP8 deficiency, and their interaction in the aortic wall.

This dataset

Open GSE326751 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE326751_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1446852 and SRA study SRP688622. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Study design

4 × Mouse suprarenal aorta RNA-seq, WT Saline, biol vs 4 × Mouse suprarenal aorta RNA-seq, WT AngII, biol vs 4 × Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol vs 4 × Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biol

Supports a between-group comparison across 16 samples.

How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM9638131 Mouse suprarenal aorta RNA-seq, WT Saline, biol rep 1 Mouse suprarenal aorta …
GSM9638132 Mouse suprarenal aorta RNA-seq, WT Saline, biol rep 2 Mouse suprarenal aorta …
GSM9638133 Mouse suprarenal aorta RNA-seq, WT Saline, biol rep 3 Mouse suprarenal aorta …
GSM9638134 Mouse suprarenal aorta RNA-seq, WT Saline, biol rep 4 Mouse suprarenal aorta …
GSM9638135 Mouse suprarenal aorta RNA-seq, WT AngII, biol rep 1 Mouse suprarenal aorta …
GSM9638136 Mouse suprarenal aorta RNA-seq, WT AngII, biol rep 2 Mouse suprarenal aorta …
GSM9638137 Mouse suprarenal aorta RNA-seq, WT AngII, biol rep 3 Mouse suprarenal aorta …
GSM9638138 Mouse suprarenal aorta RNA-seq, WT AngII, biol rep 4 Mouse suprarenal aorta …
GSM9638139 Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol rep 1 Mouse suprarenal aorta …
GSM9638140 Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol rep 2 Mouse suprarenal aorta …
GSM9638141 Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol rep 3 Mouse suprarenal aorta …
GSM9638142 Mouse suprarenal aorta RNA-seq, VAMP8-KO Saline, biol rep 4 Mouse suprarenal aorta …
GSM9638143 Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biol rep 1 Mouse suprarenal aorta …
GSM9638144 Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biol rep 2 Mouse suprarenal aorta …
GSM9638145 Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biol rep 3 Mouse suprarenal aorta …
GSM9638146 Mouse suprarenal aorta RNA-seq, VAMP8-KO AngII, biol rep 4 Mouse suprarenal aorta …

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.