GEO series
DOT1L shapes ncPRC1-target gene repression to maintain cell identity of DLBCL [CUT&Tag]
GSE327306
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2026/06/19
GPL18573
Summary
DOT1L inhibition leads to a loss of H2AK119ub1 in different GC B-DLBCL cell lines. To determine whether this loss is global or gene specific, performed H2AK119ub1 and H3K27me3 CUT&Tag in the Oci-Ly7 cell line following six days of treatment with DMSO or DOT1Li. As reference, we used a doxycycline-inducible knockdown of USP7 due to its role in ncPRC1-mediated deposition of H2AK119ub1 in Oci-Ly7 cells.
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