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Gene expression analysis of the hippocampus in ovariectomized mice following royal jelly administration

GSE327513 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/09 Platform GPL34290
Summary
Postmenopausal women may experience not only physical symptoms such as hot flashes, night sweats, and bone loss, but also psychiatric symptoms such as anxiety and depression. Hormone replacement therapy is used to treat menopausal symptoms; however, no significant beneficial effects on psychiatric symptoms have been established. In recent years, naturally derived compounds have attracted attention as effective and safe therapeutic options. One such compound, royal jelly (RJ), has anti-inflammatory, antioxidant, neuroprotective, and estrogen-like properties, and has been suggested to improve anxiety- and depression-related behaviors in postmenopausal models; however, the mechanisms underlying these effects are unclear. In this study, to clarify the efficacy of RJ against menopause-associated psychiatric symptoms and its underlying mechanisms, we analyzed changes in gene expression in the hippocampus, a brain region associated with emotional regulation, using an ovariectomized (OVX) mouse model.
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Direct links to NCBI, no account and no request form: the whole study as GSE327513_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1451234 and SRA study SRP690652. Searching any of these in the dataset finder brings you back here.

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