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Spp1 Mediates Antimony Trioxide-Induced Male Reproductive Toxicity via Regulating Inflammatory Response and Blood-Testis Barrier Integrity

GSE330989 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/05 Platform GPL34290
Summary
This study investigated the male reproductive toxicity of antimony trioxide (Sb₂O₃) using in vivo male mice and in vitro TM4 Sertoli cell models. Sb₂O₃ exposure impaired spermatogenesis, triggered inflammatory responses, and disrupted blood-testis barrier integrity by upregulating Spp1, whereas Spp1 knockdown effectively alleviated Sb₂O₃-induced inflammation, cell migration dysfunction and tight junction protein loss, identifying Spp1 as a crucial regulator of Sb₂O₃-mediated male reproductive injury.
Published in
Spp1 Contributes to Nano-Antimony Trioxide-Induced Male Reproductive Toxicity Associated with Inflammatory Response and Blood-Testis Barrier-Related Alterations
Huang Z, Zhao Y, Wang Y et al. · Toxics 2026 · PMID 42515134 · doi:10.3390/toxics14070569
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Also filed as BioProject PRJNA1466410 and SRA study SRP700635. Searching any of these in the dataset finder brings you back here.

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