IL1R1 blockade augments CD40 agonist mediated immunity in pancreatic cancer
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Liver RNA-seq agoCD40 vs 3 × Liver RNA-seq anti-IL-1R1 vs 3 × Liver RNA-seq Combo vs 3 × Liver RNA-seq isotype controlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IL1R1 blockade augments CD40 agonist mediated immunity in pancreatic cancerScientific reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE331215_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1467185 and SRA study SRP701187. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9742092 Liver RNA-seq agoCD40 replicate 1 Liver RNA-seq agoCD40
- GSM9742093 Liver RNA-seq agoCD40 replicate 2 Liver RNA-seq agoCD40
- GSM9742094 Liver RNA-seq agoCD40 replicate 3 Liver RNA-seq agoCD40
- GSM9742095 Liver RNA-seq anti-IL-1R1 replicate 1 Liver RNA-seq anti-IL-1…
- GSM9742096 Liver RNA-seq anti-IL-1R1 replicate 2 Liver RNA-seq anti-IL-1…
- GSM9742097 Liver RNA-seq anti-IL-1R1 replicate 3 Liver RNA-seq anti-IL-1…
- GSM9742098 Liver RNA-seq Combo replicate 1 Liver RNA-seq Combo
- GSM9742099 Liver RNA-seq Combo replicate 2 Liver RNA-seq Combo
- GSM9742100 Liver RNA-seq Combo replicate 3 Liver RNA-seq Combo
- GSM9742101 Liver RNA-seq isotype control replicate 1 Liver RNA-seq isotype c…
- GSM9742102 Liver RNA-seq isotype control replicate 2 Liver RNA-seq isotype c…
- GSM9742103 Liver RNA-seq isotype control replicate 3 Liver RNA-seq isotype c…
- GSE283198 Combined Flt3L and CD40 agonism restores dendritic cell driven T cell immunity in mouse models and patients with pancreatic cancer [mouse] 13 samples shares cd40, pancreatic, immunity
- GSE291447 Targeting CD11b+ regulatory B cells via RAS/RAF/PI3K pathway inhibition augments response to immune checkpoint blockade or CD40 agonism in metastatic melanoma 60 samples shares cd40, blockade, augments
- GSE298036 Fc-optimized CD40 Agonistic Antibody Induces Tertiary Lymphoid Structures and Systemic Antitumor Immunity in Metastatic Cancer Patients 33 samples shares cd40, immunity, agonist
- GSE307388 Immune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones in preclinical models of cancer 12 samples shares blockade, augments, immunity
- GSE248154 Effect of regorafenib, anti-PD1, and anti-CD40 agonist in Head and Neck Squamous Cell Carcinoma [4NQO_model] 19 samples shares cd40, agonist
- GSE325803 CD40-induced humoral immunity 18 samples shares cd40, immunity
- GSE325579 NEMO lysine mutant mice reveal ROS-RelA signaling required for optimal CD40-induced humoral immunity [NEMODK_ATACSeq] 12 samples shares cd40, immunity
- GSE266899 The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen hydroxyprolination and favoring immune infiltration. 18 samples shares pancreatic, agonist
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.