GEO series
Effect of Tyrphostin-AG4178 on ex-vivo mouse ovarian follicles in eIVFG ovulation system
GSE335098
Mus musculus
Expression profiling by high throughput sequencing
17 samples
2026/06/23
GPL30172
Summary
Ovulation is a coordinated, multicellular process carried out in the antral follicle involving gonadotropin-stimulus, cumulos-oocyte complex expansion, follicle rupture, followed by luteinization. Ovulation can be prevented by targeted inhibition of upstream signalling molecules via tool compounds such as Tyrphostin-AG4178, which binds to EGFR and thus prevents downstream MEK/ERK, prostaglandin, and Pgr signaling. We exposed ex vivo mouse ovarian follicles grown in an encapsulated in-vitro follicle growth (eIVFG) system to Tyrphostin-AG4178 after stimulus with hCG and performed bulk-RNA sequencing on whole follicles to observe the transcriptomic response to targeted ovulation inhibition.
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