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Long-term immune and extracellular matrix remodeling in the mouse cornea after open-field blast injury

GSE339117 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/04 Platform GPL24247
Summary
Open-field blast injury (OFBI) can produce long-term ocular surface abnormalities, but the chronic molecular response of the cornea remains poorly defined. In this study, awake, non-sedated C57BL/6J mice were exposed to a single open-field blast generated by detonation of 350 g Composition C-4 explosive at a 3 m standoff distance. Corneas were collected 12 months after blast exposure and compared with age-matched naïve controls using bulk RNA sequencing. Differential expression analysis identified persistent transcriptomic remodeling in OFBI corneas, with clear separation from naïve controls by principal component analysis and hierarchical clustering. The data analysis demonstrated that OFBI induces durable corneal transcriptomic remodeling 12 months after injury.
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Also filed as BioProject PRJNA1497698 and SRA study SRP719477. Searching any of these in the dataset finder brings you back here.

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