GEO series

Multi-tissue gene expression profiles of human brain (PFC)

GSE44770 Homo sapiens Expression profiling by array 230 samples Submitted 2013/04/25 Platform GPL4372

Summary

The genetics of complex disease produce alterations in molecular interactions of cellular pathways which collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer´s disease (LOAD), we constructed gene regulatory networks in hundreds of autopsied brain tissues from LOAD patients and non-demented subjects. We demonstrate that LOAD reconfigures specific portions of the molecular interaction structure, and via an integrative network-based approach we rank ordered these sub-networks (modules) for relevance to LOAD pathology, highlighting the immune/microglia module as the top ranking. Through a Bayesian inference approach we identified multiple key causal regulators for LOAD brains.

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Direct links to NCBI, no account and no request form: the whole study as GSE44770_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 230 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA191618. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23622250) ↗

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