GEO series

Multi-tissue gene expression profiles of human brain (VC)

GSE44771 Homo sapiens Expression profiling by array 230 samples Submitted 2013/04/25 Platform GPL4372

Summary

The genetics of complex disease produce alterations in molecular interactions of cellular pathways which collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer´s disease (LOAD), we constructed gene regulatory networks in hundreds of autopsied brain tissues from LOAD patients and non-demented subjects. We demonstrate that LOAD reconfigures specific portions of the molecular interaction structure, and via an integrative network-based approach we rank ordered these sub-networks (modules) for relevance to LOAD pathology, highlighting the immune/microglia module as the top ranking. Through a Bayesian inference approach we identified multiple key causal regulators for LOAD brains.

This dataset

Open GSE44771 in finder → Find more human microarray datasets →

Download

Direct links to NCBI, no account and no request form: the whole study as GSE44771_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 230 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA191619. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23622250) ↗

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 230 more — browse all 230 samples with per-sample file links →

Similar datasets

GSE7965 Blood and Adipose tissue samples 1722 samples
GSE6764 Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma 75 samples
GSE39396 Expression profiles of cell populations purified from human CRC (4 ways) 24 samples
GSE9890 Expression profile of 5 ovarian tumour samples (two different cell types from each sample profiles) 10 samples
GSE20142 Primary human leucocyte RNA expression of unrelated Dutch individuals. 1240 samples
GSE194040 I-SPY2-990 mRNA/RPPA Data Resource: mRNA component 988 samples
GSE36133 Expression data from the Cancer Cell Line Encyclopedia (CCLE) 917 samples
GSE37069 Gene response to major burn injuries 590 samples

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.