GEO series

Knock-down of BCL6 expression in human Diffuse Large B-Cell Lymphoma cell lines

GSE45838 Homo sapiens Expression profiling by array 12 samples Submitted 2013/09/01 Platform GPL570

Summary

This dataset was used to benchmark the Virtual Inference of Protein-activity by Regulon Readout algorithm (VIPER). Despite recent advances in molecular profiling, proteome-wide assessment of protein activity in individual samples remains a highly elusive target. In stark contrast, protein activity quantitation is increasingly critical to the dissection of key regulatory processes and to the elucidation of biologically relevant mechanisms. Importantly, its value extends to the study of drug activity, as most small molecules inhibit activity of their cognate protein substrates without affecting the protein’s or associated mRNA’s abundance. VIPER leverages the increasingly accurate and context specific knowledge of regulatory networks. Specifically, it uses the expression of the transcriptional targets most directly regulated by a given protein in an individual sample as a reporter for the computational inference of its activity.

This dataset

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Direct links to NCBI, no account and no request form: the whole study as GSE45838_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA196519. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 27322546) ↗

Samples in this study

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