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Single Cell RNA-sequencing of Pancreatic Circulating Tumor Cells

GSE51372 Mus musculus Expression profiling by high throughput sequencing 187 samples Submitted 2014/09/22 Platform GPL15907
Summary
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RNA-sequencing. This study was conducted to determine the heterogeneity of pancreatic CTCs and to compare these CTCs to matched primary tumors, cell line controls (NB508 cancer cell line and MEF non-cancer cell line), primary tumor single cells, and normal leukocytes/WBCs.
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Direct links to NCBI, no account and no request form: the whole study as GSE51372_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 187 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA222842 and SRA study SRP031464. Searching any of these in the dataset finder brings you back here.

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