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Long non-coding RNAs and mRNAs regulated by TGF-β

GSE54797 Homo sapiens Non-coding RNA profiling by array; Expression profiling by array 6 samples Submitted 2014/02/08 Platform GPL15314
Summary
The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB promotes the invasion-metastasis cascade, which suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for anti-metastatic therapies.
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Also filed as BioProject PRJNA237665. Searching any of these in the dataset finder brings you back here.

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