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Genome-wide expression analysis of the effects of a parasitic nematode's secreted exosomes on mammalian cells.

GSE55941 Mus musculus Expression profiling by array 11 samples Submitted 2014/12/24 Platform GPL6887
Summary
We show that a gastrointestinal nematode that infects mice, Heligmosomoides polygyrus, secretes vesicles packaged with specific microRNAs (miRNAs) and Y RNAs as well as a nematode-specific Argonaute protein. The vesicles are of intestinal origin and are enriched for homologs of mammalian proteins found in exosomes, including heat shock proteins, tetraspanins and an ESCORT protein. The nematode-derived vesicles are internalized by mouse intestinal epithelial cells and mediate changes in expression of host genes involved in inflammation and immunity, including the receptor for the alarmin IL33 as well as a key regulator of MAPK signaling, DUSP1.
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Also filed as BioProject PRJNA241398. Searching any of these in the dataset finder brings you back here.

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