GEO series

Gene expression profiling of macrophages from conventional or antibiotic-treated mice

GSE74712 Mus musculus Expression profiling by array 6 samples Submitted 2015/11/05 Platform GPL6246

Summary

Antibiotic-treated (ABX) mice exhibit an impaired innate and adaptive antiviral immune response and substantially delayed viral clearance following exposure to systemic LCMV or mucosal influenza virus. Genome-wide transcriptional profiling of macrophages isolated from ABX mice revealed decreased expression of genes associated with antiviral immunity. Moreover, macrophages from ABX mice exhibited defective responses to type I and type II IFNs and impaired capacity to limit viral replication. Collectively, these data indicate that commensal-derived signals provide tonic immune stimulation that establishes the activation threshold of the innate immune system required for optimal antiviral immunity. In this study, we performed gene expression profiling to compare the transcriptional signatures of macrophages isolated from mice exposed to commensal bacteria-derived signals to macrophages isolated from mice depleted of commensal bacteria.

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Direct links to NCBI, no account and no request form: the whole study as GSE74712_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA301238. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 22705104) ↗

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