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METTL3 promotes translation in human cancer cells

GSE76367 Homo sapiens Expression profiling by high throughput sequencing; Other 11 samples Submitted 2016/01/01 Platform GPL11154
Summary
we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translation through an interaction with the translation initiation machinery.
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Also filed as BioProject PRJNA307106 and SRA study SRP067836. Searching any of these in the dataset finder brings you back here.

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