METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 21 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- METTL3-dependent m6A RNA methylation regulates transposable elements and represses human naïve pluripotency through transposable element-derived enhancersNucleic acids research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275737_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1152879 and SRA study SRP528831. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8483682 H9 hESC, METTL3, Replicate 1, ChIP
- GSM8483683 H9 hESC METTL3 Replicate 2
- GSM8483684 H9 hESC Input
- GSM8483685 TSC, METTL3, Replicate 1, ChIP
- GSM8483686 TSC, METTL3, Replicate 2, ChIP
- GSM8483687 TSC, Input
- GSM8483688 HDF, METTL3, Replicate 1, ChIP
- GSM8483689 HDF, METTL3, Replicate 2, ChIP
- GSM8483690 HDF, Input
- GSM8483691 EPSC in P0, METTL3, Replicate 1, ChIP
- GSM8483692 EPSC in P0, METTL3, Replicate 2, ChIP
- GSM8483693 EPSC in P0, H3K9me3, Replicate 1, ChIP
- GSM8483694 EPSC in P0, H3K9me3, Replicate 2, ChIP
- GSM8483695 EPSC in P0, H3K27ac, Replicate 1, ChIP
- GSM8483696 EPSC in P0, H3K27ac, Replicate 2, ChIP
- GSM8483697 EPSC in P0, Input
- GSM8483698 EPSC in P2, H3K9me3, Replicate 1, ChIP
- GSM8483699 EPSC in P2, H3K9me3, Replicate 2, ChIP
- GSM8483700 EPSC in P2, H3K27ac, Replicate 1, ChIP
- GSM8483701 EPSC in P2, H3K27ac, Replicate 2, ChIP
- GSM8483702 EPSC in P2, Input
- GSE275738 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells 72 samples shares mettl3-dependent, transposable, pluripotency, methylation, pluripotent, represses, enhancers, elements
- GSE274217 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells [RNA-Seq] 28 samples shares mettl3-dependent, transposable, pluripotency, methylation, pluripotent, represses, enhancers, elements
- GSE283600 LINE-1 transposable elements regulate the exit of human pluripotency and early brain development 83 samples shares transposable, pluripotency, elements
- GSE283597 LINE-1 transposable elements regulate the exit of human pluripotency and early brain development [bulkRNA-seq] 45 samples shares transposable, pluripotency, elements
- GSE254244 Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes 112 samples shares transposable, elements
- GSE261306 Early Prediction of Preeclampsia Based on Transposable Elements Deregulation in the Placenta [RNA-Seq] 30 samples shares transposable, elements
- GSE309187 Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency 26 samples shares pluripotency, enhancers
- GSE216483 METTL3-dependent m6A RNA methylation regulates activation of the NLRP3 inflammasome 18 samples shares mettl3-dependent, methylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.