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Acsl4 Determines Ferroptosis Sensitivity by Shaping Cellular Lipid Composition

GSE86384 Mus musculus Expression profiling by array 12 samples Submitted 2017/06/01 Platform GPL6885
Summary
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may be exploited to modulate this form of cell death are needed. We applied two independent approaches, a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines to uncover acyl-CoA synthetase long-chain family member 4 (Acsl4) as an essential component for ferroptosis execution.
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Also filed as BioProject PRJNA341584. Searching any of these in the dataset finder brings you back here.

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