GEO series

Defective Decidualization During and After Severe Preeclampsia Reveals a Possible Maternal Contribution to the Etiology

GSE94643 Homo sapiens (human) Expression microarray 16 samples Submitted 2017/02/08 Platform GPL16686

At a glance

Expression microarray · human · 16 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Homo sapiens (human)
Samples: 16 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta’s role has been a focus. We hypothesized that decidual defects are an important determinant of the placental phenotype. We isolated (human) endometrial stromal cells (hESCs) from non-pregnant donors with a prior pregnancy that was complicated by severe PE (sPE).

Read the full summary ↓

Versus controls, they failed to decidualize as demonstrated by morphological criteria and the analysis of stage-specific antigens. These results were bolstered by showing that they were transcriptionally inert. Additionally, we used laser microdissection to isolate the decidua from tissue sections of the maternal-fetal interface. Transcriptional profiling revealed sPE-associated defects in gene expression. Also, decidual cells from sPE patients, which de-differentiated in vitro, failed to re-decidualize in culture. Immediately following isolation they released factors that inhibited CTB invasion, linking a possible cause to a known effect. These data suggested that failed decidualization is an important contributor to down regulated CTB invasion in sPE. Diagnosis of this defect prior to pregnancy would enable therapies that are designed to improve decidualization, a novel strategy for prevention.

This dataset

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Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE94643_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA371721. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 28923940) ↗

Samples in this study

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+ 16 more — browse all 16 samples with per-sample file links →

Datasets on a similar topic

GSE94644 Defective Decidualization During and After Severe Preeclampsia 36 samples shares decidualization, preeclampsia, defective, severe
GSE319236 Spatially resolved maternal and fetal cell contributions to severe Preeclampsia 152 samples shares preeclampsia, contribution, maternal, severe
GSE91077 Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE). 20 samples shares decidualization, preeclampsia, severe
GSE265862 Mapping Decidualization Resistance in Former Severe Preeclampsia Patients at Multi-Omic Levels 23 samples shares decidualization, preeclampsia, severe
GSE306127 Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of VDR in the epigenomic network [CUT&Run] 48 samples shares decidualization, defective
GSE284329 Multi-Omics Profiling Reveals Distinct Lipidomic and Transcriptomic Alterations in Gestational Diabetes Mellitus, Preeclampsia, and Coexistence of Both: Implications for Maternal and Neonatal Outcomes 17 samples shares preeclampsia, maternal
GSE287645 Maternal cause of early-onset preeclampsia: excessive endometrial gland-derived apolipoprotein D induces placental ferroptosis and developmental abnormalities 16 samples shares preeclampsia, maternal
GSE262745 Predictive biomarkers and maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology 11 samples shares preeclampsia, maternal

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