microRNA switch reveals the role of LIN28A-let-7a-5p-NR6A1 axis in megakaryocytes for platelet biogenesis
RNA-seq (gene expression) · human · 2 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE145481_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA607294 and SRA study SRP249848. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE310060 Efficient Chemical Reprogramming of Human T Cells into Functional Megakaryocytes and Platelets 24 samples shares megakaryocytes, platelet
- GSE262125 Paraspeckle-Independent Co-Transcriptional Regulation of Nuclear microRNA Biogenesis by SFPQ [RNA-seq] 24 samples shares biogenesis, microrna
- GSE242369 Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses 19 samples shares megakaryocytes, platelet
- GSE216593 Generation of megakaryocytes and functional platelets from human embryonic stem cells 18 samples shares megakaryocytes, platelet
- GSE260954 Effect of iPSC-derived megakaryocytes and platelets on gene expression of HUVEC 12 samples shares megakaryocytes, platelet
- GSE295199 KCNN4 mediated potassium ion efflux maintains mitochondrial functions leading to platelet biogenesis 10 samples shares biogenesis, platelet
- GSE280271 Deep sequencing of microRNA and total RNA reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine neoplasia from non-diseased pancreas tissue [RNA-seq] 13 samples shares microrna
- GSE324961 microRNA-132 attenuates inflammation in induced pluripotent stem-cell derived microglia from Alzheimer’s disease patients 95 samples shares microrna
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.