Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism
Expression microarray · mouse · 6 samples
- What it is
- Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
- Organism
- Mus musculus (mouse)
- Samples
- 6 samples: 3 × Control liver_4 pm vs 3 × SIRT1 LKO liver_4 pmGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Read the full summary ↓
Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need.
Whole study · RAW.tar
Everything the authors deposited as one archive (GSE14921_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.
What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.
Also filed as BioProject PRJNA111907. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 2 replicated groups read from 6 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM371988 Control liver_4 pm_rep1 Control liver_4 pm
- GSM371989 Control liver_4 pm_rep2 Control liver_4 pm
- GSM371990 Control liver_4 pm_rep3 Control liver_4 pm
- GSM371991 SIRT1 LKO liver_4 pm_rep1 SIRT1 LKO liver_4 pm
- GSM371992 SIRT1 LKO liver_4 pm_rep3 SIRT1 LKO liver_4 pm
- GSM371993 SIRT1 LKO liver_4 pm_rep2 SIRT1 LKO liver_4 pm
- GSE309118 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice 42 samples shares hepatocyte-specific, deletion
- GSE309115 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice [RNA-seq AVITI] 24 samples shares hepatocyte-specific, deletion
- GSE309117 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice [RNA-seq Illumina] 18 samples shares hepatocyte-specific, deletion
- GSE328680 Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in MASLD Progression 12 samples shares hepatocyte-specific, deletion
- GSE328885 Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice 34 samples shares sirt1
- GSE32309 Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion 12 samples shares deletion
- GSE267592 Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism (Brain Endo Bulk Seq) 10 samples shares alters
- GSE246119 Dynamic dysregulation of the transcriptome upon deletion of Mecp2 in adult mice 144 samples shares deletion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.