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Transcriptome sequencing of liver tissue in hepatocyte-specific IRF8-deficient mice (IRF8-cKO) mice and wild type (WT) mice that were subjected to warm ischemia/reperfusion(I/R) injury

GSE171982 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/13 Platform GPL24247
Summary
Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding protein, is an essential lineage-specific transcriptional regulator in the IRF family, controls diverse cellular processes and is has been implicated in innate immunity, immune cell differentiation. IRF8 has been shown to have both oncogenic and tumor suppressor activities, in myeloid cells and nonhematopoietic cells. As a transcription factor, other functions which may contribute to its oncogenic and anti tumor potential are not clear. So it is meaningful to study the role of IRF8 in different diseases. Our recent study demonstrated the protective effects of IRF8 on the liver cancer through the regulation of immune response. In addition, studies have shown that IRF8 has protective effects on ischemia-reperfusion injury of heart and brain and we wondered. However, the role of IRF8 in hepatic ischemia-reperfusion injury has not been reported.
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Also filed as BioProject PRJNA721613 and SRA study SRP314640. Searching any of these in the dataset finder brings you back here.

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