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High-Fructose Corn Syrup Promotes Proinflammatory Macrophage Activation via ROS-Mediated NF-κB Signaling and Exacerbates Colitis in Mice

GSE186953 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/01 Platform GPL24247
Summary
we focused on HFCS and found that HFCS aggravates colitis by altering the intestinal immune microenvironment. Our data demonstrate that short-term consumption of HFCS upregulates the proportion of macrophages in IBD mice but not in healthy mice. HFCS promotes proinflammatory cytokine production through reactive oxygen species (ROS)-mediated nuclear factor-κB (NF-κB) signaling. Our work unveils the important role of macrophages in HFCS-induced exacerbation of colitis and reveals the mechanism of how HFCS immunologically aggravates IBD.
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Also filed as BioProject PRJNA776868 and SRA study SRP344055. Searching any of these in the dataset finder brings you back here.

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