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OPTN as a therapeutic target for acetaminophen-induced liver injury by activating mitophagy

GSE195753 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/21 Platform GPL21103
Summary
Acetaminophen (APAP) is a leading cause of acute liver failure in Western countries result from the accumulation of damaged mitochondria. However, there is no related clinically useful therapeutic intervention. Optineurin (OPTN) is a multifunctional protein involved in autophagy, oxidative stress, as well as nuclear factor κB (NF-κB) and IRF3 signaling, and OPTN mutations are associated with several human diseases.Here, to study the role of OPTN in APAP induced liver injury, we performed RNA-seq analysis of isolated control and Optn-/- mouse liver tissues.
Published in
Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy
Wang J, Qiu Y, Yang L et al. · Autophagy 2024 · PMID 39099169 · doi:10.1080/15548627.2024.2384348
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Also filed as BioProject PRJNA802056 and SRA study SRP357475. Searching any of these in the dataset finder brings you back here.

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