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Oncostatin M signaling drives cancer-associated skeletal muscle wasting

GSE222208 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/21 Platform GPL24247
Summary
Investigating muscle wasting in a murine model of cancer cachexia, we identified Oncostatin M (OSM) as a potential mediator of inflammatory responses in skeletal muscle. OSM is a member of the IL-6 family of cytokines and has crucial functions in cell growth, differentiation, and inflammation. Our results demonstrate that OSM induces muscle atrophy. To understand if its effect is specific or it is a general effect of IL6 family cytokines, primary myotubes were treated with OSM, IL6 and LIF for 48hrs. Our findings showed that OSM potently induces muscle wasting in differentiated myotubes.
Published in
Oncostatin M signaling drives cancer-associated skeletal muscle wasting
Domaniku-Waraich A, Agca S, Toledo B et al. · Cell reports. Medicine 2024 · PMID 38569555 · doi:10.1016/j.xcrm.2024.101498
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Also filed as BioProject PRJNA918601 and SRA study SRP415953. Searching any of these in the dataset finder brings you back here.

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