GEO series
Transcriptomic profiling performed in bladder carcinomas collected from Neodurvarib clinical trial (NCT03534492)
GSE225066
Homo sapiens
Expression profiling by high throughput sequencing
26 samples
2025/01/17
GPL20301
Summary
RNASeq profiling of bladder carcinomas from different histologies (urothelial carcinomas or squamous cell carcinomas) which were collected at different moments of the Neodurvarib-related clinical procedure (pretreatment ("SCR") or post-treatment ("Q")). The main goals of the screening were 1) to define potential predictive/prognostic biomarkers (genes or molecular pathways) through the comparison of diagnostic samples ("SCR") according to the clinical response observed in the patients under study; ii) to evaluate the molecular changes observed in the tumors under study by comparing the profiles of diagnostic samples ("SCR") versus cystectomies ("Q"), which would be a direct consequence of the neoadjuvant therapy used in this clinical trial.
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Paper (PMID 40298406) ↗
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