Enhancer plasticity in endometrial tumorigenesis demarcates non-coding driver mutations and 3D genome alterations to stimulate oncogene expression
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 36 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Endometrial cancerThis series is part of our curated briefing on it.
- Samples
- 36 samples: 34 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterationsGenome biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235241_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA985607 and SRA study SRP485249. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 36 sample titles: 34 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7497555 H1.12.ER
- GSM7497556 H1.12.H3K27ac
- GSM7497557 H1.147.ER
- GSM7497558 H1.147.H3K27ac
- GSM7497559 H2.A.ER
- GSM7497560 H2.A.K27ac
- GSM7497561 H2.B.ER
- GSM7497562 H2.B.H3K27ac
- GSM7497563 T102.ER
- GSM7497564 T102.H3K27ac
- GSM7497565 T119.ER
- GSM7497566 T119.H3K27ac
- GSM7497567 T33.ER
- GSM7497568 T33.H3K27ac
- GSM7497569 T5.ER
- GSM7497570 T5.H3K27ac
- GSM7497571 T55.ER
- GSM7497572 T55.H3K27ac
- GSM8029974 Ishikawa_INPUT_6h_DMSO_rep1-2
- GSM8029975 Ishikawa_INPUT_6h_10nM.E2_rep1-2
- GSM8029976 Ishikawa_G9a_6h_DMSO_rep1
- GSM8029977 Ishikawa_G9a_6h_10nM.E2_rep1
- GSM8029978 Ishikawa_G9a_6h_DMSO_rep2
- GSM8029979 Ishikawa_G9a_6h_10nM.E2_rep2
- GSM8029980 RNAseq_H.005.A2
- GSM8029981 RNAseq_T.039.II1
- GSM8029982 RNAseq_T.081.A1
- GSM8029983 RNAseq_H.069.C2
- GSM8029984 RNAseq_T.001.A1
- GSM8029985 RNAseq_H.081.A2
- GSM8524910 Hi-C_H.005.A2
- GSM8524911 Hi-C_H.069.C2
- GSM8524912 Hi-C_H.081.A2
- GSM8524913 Hi-C_T.001.A1
- GSM8524914 Hi-C_T.039.II1
- GSM8524915 Hi-C_T.081.A1
- GSE289181 FBXW7 Mutations Reprograms Glucose Metabolism by Activating the ETV6-GLUT Axis in Endometrial Cancer 6 samples same disease briefing · shares endometrial, mutations
- GSE307568 Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer 189 samples same disease briefing · shares endometrial
- GSE212217 Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma 104 samples same disease briefing · shares endometrial
- GSE17025 Gene Expression Analysis of Stage I Endometrial Cancers 103 samples same disease briefing · shares endometrial
- GSE323968 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer 56 samples same disease briefing · shares endometrial
- GSE247793 Cell cycle checkpoint proficiency of endometrial cancer cells 42 samples same disease briefing · shares endometrial
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples same disease briefing · shares endometrial
- GSE312906 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer 37 samples same disease briefing · shares endometrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.