Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer
RNA-seq (gene expression) · human · 56 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Endometrial cancerThis series is part of our curated briefing on it.
- Samples
- 56 samples: 39 × RNAseq, Patient vs 17 × WES, patientGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE323968_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1432765. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 56 samples.
How we read this: 2 replicated groups read from 56 sample titles; they account for 56 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9565689 RNAseq, Patient 6 RNAseq, Patient
- GSM9565690 RNAseq, Patient 7 RNAseq, Patient
- GSM9565691 RNAseq, Patient 10 RNAseq, Patient
- GSM9565692 RNAseq, Patient 11 RNAseq, Patient
- GSM9565693 RNAseq, Patient 12 RNAseq, Patient
- GSM9565694 RNAseq, Patient 13 RNAseq, Patient
- GSM9565695 RNAseq, Patient 14 RNAseq, Patient
- GSM9565696 RNAseq, Patient 15 RNAseq, Patient
- GSM9565697 RNAseq, Patient 22 RNAseq, Patient
- GSM9565698 RNAseq, Patient 23 RNAseq, Patient
- GSM9565699 RNAseq, Patient 25 RNAseq, Patient
- GSM9565700 RNAseq, Patient 27 RNAseq, Patient
- GSM9565701 RNAseq, Patient 28 RNAseq, Patient
- GSM9565702 RNAseq, Patient 29 RNAseq, Patient
- GSM9565703 RNAseq, Patient 30 RNAseq, Patient
- GSM9565704 RNAseq, Patient 31 RNAseq, Patient
- GSM9565705 RNAseq, Patient 32 RNAseq, Patient
- GSM9565706 RNAseq, Patient 33 RNAseq, Patient
- GSM9565707 RNAseq, Patient 34 RNAseq, Patient
- GSM9565708 RNAseq, Patient 35 RNAseq, Patient
- GSM9565709 RNAseq, Patient 36 RNAseq, Patient
- GSM9565710 RNAseq, Patient 37 RNAseq, Patient
- GSM9565711 RNAseq, Patient 38 RNAseq, Patient
- GSM9565712 RNAseq, Patient 41 RNAseq, Patient
- GSM9565713 RNAseq, Patient 42 RNAseq, Patient
- GSM9565714 RNAseq, Patient 43 RNAseq, Patient
- GSM9565715 RNAseq, Patient 44 RNAseq, Patient
- GSM9565716 RNAseq, Patient 46 RNAseq, Patient
- GSM9565717 RNAseq, Patient 47 RNAseq, Patient
- GSM9565718 RNAseq, Patient 48 RNAseq, Patient
- GSM9565719 RNAseq, Patient 49 RNAseq, Patient
- GSM9565720 RNAseq, Patient 50 RNAseq, Patient
- GSM9565721 RNAseq, Patient 53 RNAseq, Patient
- GSM9565722 RNAseq, Patient 55 RNAseq, Patient
- GSM9565723 RNAseq, Patient 56 RNAseq, Patient
- GSM9565724 RNAseq, Patient 57 RNAseq, Patient
- GSM9565725 RNAseq, Patient 58 RNAseq, Patient
- GSM9565726 RNAseq, Patient 59 RNAseq, Patient
- GSM9565727 RNAseq, Patient 60 RNAseq, Patient
- GSM9565728 WES, patient 6 WES, patient
+ 16 more — browse all 56 samples with per-sample file links →
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples same disease briefing · shares cdk4, endometrial, signatures, indicating, inhibition, predict
- GSE272263 Adipocyte induced distinct gene expression profiling of human endometrioid endometrial cancer cells upon SIRT1 inhibition. 5 samples same disease briefing · shares endometrial, inhibition
- GSE167548 Expression profile of transcripts associated with Apcin-induced growth inhibition and apoptosis in endometrial carcinoma 8 samples same disease briefing · shares endometrial, inhibition
- GSE268903 Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study 10 samples same disease briefing · shares endometrial
- GSE307568 Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer 189 samples same disease briefing · shares endometrial
- GSE17025 Gene Expression Analysis of Stage I Endometrial Cancers 103 samples same disease briefing · shares endometrial
- GSE278879 Single nucleus RNA sequencing analysis reveals transcriptional heterogeneity of endometrioid endometrial cancer 11 samples same disease briefing · shares endometrial
- GSE247793 Cell cycle checkpoint proficiency of endometrial cancer cells 42 samples same disease briefing · shares endometrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.