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Bulk RNA-seq of sham or alkali injury treated WT and Vegfr3 depletion mouse iris

GSE240269 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/05/29 Platform GPL23479
Summary
We report conditional ablation of lymphatic Vegfr3 alleviated inflammatory process in alkali injured iris. Prox1CreERT2 mice were crossed with Vegfr3fl/fl to selectively target gene expression in Prox1+ lymphatic cells. Injury models were established at 6 weeks postnatally, and Vegfr3 gene depletion was conducted via Tamoxifen injection on the day 13th-17th after corneal alkali injury. Mice were sacrificed 28th days post-injury.
Published in
Alkali injury-induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation
Liu Z, Liu K, Shi S et al. · JCI insight 2024 · PMID 38587075 · doi:10.1172/jci.insight.175479
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Also filed as BioProject PRJNA1003075 and SRA study SRP453811. Searching any of these in the dataset finder brings you back here.

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