Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 36 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic StudyJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241361_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1007747 and SRA study SRP456216. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 16 samples read as cases, 8 as controls.
How we read this: Read from 36 sample titles: 36 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7727661 Sample A1, No treated, Wild type, Dorsal root ganglion
- GSM7727662 Sample A2, No treated, Wild type, Dorsal root ganglion
- GSM7727663 Sample A3, No treated, Wild type, Dorsal root ganglion
- GSM7727664 Sample A4, No treated, Wild type, Dorsal root ganglion
- GSM7727665 Sample A5, No treated, Wild type, Spinal cord
- GSM7727666 Sample A6, No treated, Knockout, Spinal cord
- GSM7727667 Sample A7, No treated, Wild type, Spinal cord
- GSM7727668 Sample A8, No treated, Knockout, Spinal cord
- GSM7727669 Sample B1, No treated, Wild type, Dorsal root ganglion
- GSM7727670 Sample B2, No treated, Knockout, Dorsal root ganglion
- GSM7727671 Sample B3, No treated, Wild type, Dorsal root ganglion
- GSM7727672 Sample B4, No treated, Knockout, Dorsal root ganglion
- GSM7727673 Sample B5, No treated, Wild type, Spinal cord
- GSM7727674 Sample B6, No treated, Knockout, Spinal cord
- GSM7727675 Sample B7, No treated, Wild type, Spinal cord
- GSM7727676 Sample B8, No treated, Knockout, Spinal cord
- GSM7727677 Sample C1, No treated, Wild type, Dorsal root ganglion
- GSM7727678 Sample C2, No treated, Knockout, Dorsal root ganglion
- GSM7727679 Sample C5, No treated, Wild type, Spinal cord
- GSM7727680 Sample C6, No treated, Knockout, Spinal cord
- GSM7727681 Sample E1, Spared nerve injury, Wild type, Dorsal root ganglion
- GSM7727682 Sample E2, Spared nerve injury, Knockout, Dorsal root ganglion
- GSM7727683 Sample E3, Spared nerve injury, Wild type, Dorsal root ganglion
- GSM7727684 Sample E4, Spared nerve injury, Knockout, Dorsal root ganglion
- GSM7727685 Sample E5, Spared nerve injury, Wild type, Spinal cord
- GSM7727686 Sample E6, Spared nerve injury, Knockout, Spinal cord
- GSM7727687 Sample E7, Spared nerve injury, Wild type, Spinal cord
- GSM7727688 Sample E8, Spared nerve injury, Knockout, Spinal cord
- GSM7727689 Sample F1, Spared nerve injury, Wild type, Dorsal root ganglion
- GSM7727690 Sample F2, Spared nerve injury, Knockout, Dorsal root ganglion
- GSM7727691 Sample F3, Spared nerve injury, Wild type, Dorsal root ganglion
- GSM7727692 Sample F4, Spared nerve injury, Knockout, Dorsal root ganglion
- GSM7727693 Sample F5, Spared nerve injury, Wild type, Spinal cord
- GSM7727694 Sample F6, Spared nerve injury, Knockout, Spinal cord
- GSM7727695 Sample F7, Spared nerve injury, Wild type, Spinal cord
- GSM7727696 Sample F8, Spared nerve injury, Knockout, Spinal cord
- GSE172064 Comparing axon regeneration in male and female mice after peripheral nerve injury 12 samples shares peripheral, injury, female
- GSE302808 Depletion of Peripheral Monocytes Alters Long-Term Gene Expression in Microglia in a Murine Model of Traumatic Brain Injury 84 samples shares peripheral, injury
- GSE273220 Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice 72 samples shares peripheral, injury
- GSE283560 Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury III 65 samples shares peripheral, injury
- GSE240708 Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females 53 samples shares peripheral, female
- GSE261492 Hypertension Promotes Neuroinflammation, Brain Injury and Cognitive Impairment 48 samples shares neuroinflammation, injury
- GSE312514 Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury 24 samples shares peripheral, injury
- GSE269326 Nucleus Accumbens MEF2C Mediates the Maintenance of Peripheral Nerve Injury-induced Physiological and Behavioral Maladaptations 24 samples shares peripheral, injury
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.