Double Negative T Cells Downregulate Intrahepatic Inflammation and Ameliorate Hepatic Ischemia and Reperfusion Injury via CD39-adenosinergic axis
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Purinergic signaling by TCRαβ(+) double-negative T regulatory cells ameliorates liver ischemia-reperfusion injuryScience bulletin · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246302_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1032455 and SRA study SRP468566. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 20 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7866435 WT-1 WT
- GSM7866436 WT-2 WT
- GSM7866437 WT-3 WT
- GSM7866438 WTATPgs-1 WTATPgs
- GSM7866439 WTATPgs-2 WTATPgs
- GSM7866440 WTATPgs-3 WTATPgs
- GSM7866441 DNT-1 DNT
- GSM7866442 DNT-2 DNT
- GSM7866443 DNT-3 DNT
- GSM7866444 ADO-1 ADO
- GSM7866445 ADO-2 ADO
- GSM7866446 ADO-3 ADO
- GSM7866447 R-1
- GSM7866448 R-2
- GSM7866449 R-3
- GSM7866450 RA-1 RA
- GSM7866451 RA-2 RA
- GSM7866452 RA-3 RA
- GSM7866453 AG
- GSM7866454 AF
- GSE246300 Double Negative T Cells Downregulate Intrahepatic Inflammation and Ameliorate Hepatic Ischemia and Reperfusion Injury via CD39-adenosinergic axis [RNA-seq] 18 samples shares cd39-adenosinergic, downregulate, intrahepatic, reperfusion, ameliorate, negative, ischemia, hepatic
- GSE302628 Evaluation of the pharmacological effects of oridonin on hepatic ischemia/reperfusion injury in vivo 18 samples shares reperfusion, ischemia, hepatic
- GSE309904 Acute kidney injury following fatty liver ischemia-reperfusion injury: indirect protection by hepatic ferroptosis inhibition 12 samples shares reperfusion, ischemia, hepatic
- GSE247263 Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury 9 samples shares reperfusion, ameliorate, ischemia
- GSE252255 METTL3 deficiency aggravates hepatic ischemia/reperfusion injury in mice by activating the MAPK signaling pathway 8 samples shares reperfusion, ischemia, hepatic
- GSE293329 Btg2 Inhibits the UFMylation of Fmo1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury in Mice 6 samples shares reperfusion, ischemia, hepatic
- GSE296317 Hepatic NcoR1 deletion exacerbates ischemia and reperfusion (IR) induced liver injury regulated by NF-kB p65 [sham-IR] 6 samples shares reperfusion, ischemia, hepatic
- GSE246406 Nuclear Acly protects liver from ischemia-reperfusion injury 27 samples shares reperfusion, ischemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.