A ketogenic diet prevents metabolic switching durng time restricted feeding
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248299_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1043176 and SRA study SRP473353. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7911127 20462X1_Liver_Control_ALF_replicate1
- GSM7911128 20462X2_Liver_Control_ALF_replicate2
- GSM7911129 20462X3_Liver_HFD_ALF_replicate1
- GSM7911130 20462X4_Liver_HFD_ALF_replicate2
- GSM7911131 20462X8_Liver_Keto_ALF_replicate1
- GSM7911132 20462X9_Liver_Keto_ALF_replicate2
- GSM7911133 20462X13_Liver_HFD_ALF_replicate3
- GSM7911134 20462X14_Liver_HFD_ALF_replicate4
- GSM7911135 20462X15_Liver_HFD_ALF_replicate5
- GSM7911136 20462X18_Liver_Control_ALF_replicate3
- GSM7911137 20462X19_Liver_Control_ALF_replicate4
- GSM7911138 20462X20_Liver_Control_ALF_replicate5
- GSM7911139 20462X23_Liver_Keto_ALF_replicate3
- GSM7911140 20462X24_Liver_Keto_ALF_replicate4
- GSM7911141 20462X25_Liver_Keto_ALF_replicate5
- GSE267751 Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signaling. 71 samples shares restricted, prevents, feeding, diet, time
- GSE264350 Disruption of the Circadian Rhythm Is Exacerbated by Aging and Partially Restored by Time-restricted Feeding 78 samples shares restricted, feeding, time
- GSE210460 Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice 24 samples shares restricted, feeding, time
- GSE283692 A ketogenic diet and voluntary exercise modify the sciatic nerve and gastrocnemius transcriptome in diet-induced obese mice 96 samples shares ketogenic, diet
- GSE204856 Immunoregulation of Intrahepatic Bone Marrow Monocyte–Derived Macrophages by Dietary Nitrate Prevents Nonalcoholic Fatty Liver Disease 24 samples shares prevents, diet
- GSE314901 Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools 20 samples shares ketogenic, diet
- GSE301153 A ketogenic diet improves memory in females in the APOE4 mouse model of Alzheimer’s disease. 20 samples shares ketogenic, diet
- GSE224831 Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [Prox1 OE iHep Timecourse RNA-seq] 16 samples shares prevents, time
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.