Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 19 samples: 4 × N vs 4 × cko vs 3 × Ct vs 3 × IGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248639_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1045290 and SRA study SRP474262. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 19 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7918288 Lin_1_Chip_Seq_for_Nynrin
- GSM7918289 Lin_1_input_for_Nynrin
- GSM7918290 Lin_2_Chip_Seq_for_Nynrin
- GSM7918291 Lin_2_input_for_Nynrin
- GSM7918292 Ctr_1 Ct
- GSM7918293 Ctr_2 Ct
- GSM7918294 Ctr_3 Ct
- GSM7918295 IR_1 I
- GSM7918296 IR_2 I
- GSM7918297 IR_3 I
- GSM7918298 N1 N
- GSM7918299 N2 N
- GSM7918300 N3 N
- GSM7918301 N4 N
- GSM7918302 cko1 cko
- GSM7918303 cko2 cko
- GSM7918304 cko3 cko
- GSM7918305 cko4 cko
- GSM7918306 Lin- cells_scRNA-seq
- GSE242821 Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics 26 samples shares mitochondrial, transition
- GSE242820 Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics [snRNA-seq] 5 samples shares mitochondrial, transition
- GSE261634 Mutant p53 alters chromatin accessibility in hematopoietic stem and progenitor cells. 37 samples shares hematopoietic
- GSE239815 Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs 307 samples shares mitochondrial
- GSE342640 Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation 159 samples shares mitochondrial
- GSE293066 MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by 2 Preserving Mitochondrial Integrity 54 samples shares mitochondrial
- GSE309285 CK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation 53 samples shares hematopoietic
- GSE282765 Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic Spp1+ macrophage differentiation. 42 samples shares inhibiting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.