← BioTransfer GEO Dataset Finder
GEO series

Bulk RNA-seq of mouse bone marrow derived macrophages co-cultured with platelets

GSE262128 Mus musculus (mouse) RNA-seq (gene expression) 16 samples Submitted 2025/08/11 Platform GPL30172
At a glance

RNA-seq (gene expression) · mouse · 16 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
16 samples: 4 × BMDM treated with vehicle vs 4 × BMDM treated with resting platelets vs 4 × BMDM treated with Thrombin vs 4 × BMDM treated with thrombin-activated plateletsGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Platelets drive macrophage inflammatory activation in vitroJournal of leukocyte biology · 2025
Summary (written by the submitters)
We performed bulk RNA-seq gene expression analysis of macrophages co-cultured with resting or activated platelets
Published in
Platelets drive macrophage inflammatory activation in vitro
Rizakou A, Rosa A, Weiss LJ et al. · Journal of leukocyte biology 2025 · PMID 40795250 · doi:10.1093/jleuko/qiaf114
This dataset
Open GSE262128 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262128_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1090441 and SRA study SRP496974. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40795250) ↗
Study design
4 × BMDM treated with vehicle vs 4 × BMDM treated with resting platelets vs 4 × BMDM treated with Thrombin vs 4 × BMDM treated with thrombin-activated platelets

Supports a between-group comparison across 16 samples.

How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.