GEO series
Optimized reporters for multiplexed detection of transcription factor activity
GSE267969
Homo sapiens; Mus musculus
Expression profiling by high throughput sequencing
14 samples
2024/05/26
GPL24676GPL24247
Summary
A library of 35,500 reporters was designed for 86 TFs in order to identify optimized TF reporters. The library was transfected into diverse cell types and probed upon almost 100 TF perturbations. To compare TF activities with TF abundances, RNA-seq data was used. For mNPCs, mESCs and HepG2 cells, RNA-seq data was generated in house. For thee TF knockdowns in HepG2 cells, RNA-seq data was generated to validate the experimental design.
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Paper (PMID 39091757) ↗
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