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LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate DKD in diabetic mice

GSE269534 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/12/26 Platform GPL24247
Summary
scRNA-seq analysis confirmed that increased LRG1 is limited to GECs in early diabetic kidneys. As anticipated, LRG1 loss significantly attenuated diabetic glomerulopathy including podocyte loss, and improved renal function. scRNA-seq analysis demonstrated that LRG1 loss was sufficient to reverse all significant molecular pathway changes in diabetic mouse GECs, which were also associated with the dampening of TGF-β-induced gene expression. Moreover, LRG1 loss also led to a significant attenuation of TGF-β-mediated gene expression in podocytes and mesangial cells of diabetic mice. These results indicate that increased LRG1 directly potentiates TGF-β signaling in glomerular cells in an autocrine and paracrine manner to promote DKD, and indirectly via glomerular cross-talk.
Published in
LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease
Wang X, Sun Z, Fu J et al. · Molecular therapy : the journal of the American Society of Gene Therapy 2024 · PMID 38910328 · doi:10.1016/j.ymthe.2024.06.027
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Also filed as BioProject PRJNA1122216 and SRA study SRP513054. Searching any of these in the dataset finder brings you back here.

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