GEO series
Myocardial Reprogramming by HMGN1 Underlies Heart Defects in Trisomy 21
GSE271447
Homo sapiens (human)
ChIP-seq / ATAC-seq (genome binding and open chromatin)
84 samples
Submitted 2025/08/25
Platform GPL21103Platform GPL20301Platform GPL24676Platform GPL18573
At a glance
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 84 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 84 samples: 64 distinct titles, 11 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21Nature · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Ranade SS, Li F, Whalen S et al.
· Nature 2025
· PMID 41125893
· doi:10.1038/s41586-025-09593-9
This dataset
Download · which file do I need?
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
1 · Just have a look
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
2 · Re-analyse it
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271447_RAW.tar (it can run to tens of gigabytes).
3 · Start from the raw reads
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1131436 and SRA study SRP517831. Searching any of these in the dataset finder brings you back here.
Study design
64 distinct titles, 11 of them repeated
scRNA_CROPtimecourse_endogenous_CROP ×6
scRNA_CROPtimecourse_amplicon_CROP ×6
scRNA_E115_tg ×3
CnR_HMGN1 ×2
scRNA_E115_wt ×2
scRNA_E115_het ×2
scRNA_VPR_DSCAM ×2
scRNA_VPR_DYRK1A ×2
+3 more
How we read this: Read from 84 sample titles: 64 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
Samples in this study
- GSM8377062 Disomic Day 10 hiPSC-CM, Replicate 1, scRNAseq
- GSM8377063 Disomic Day 10 hiPSC-CM, Replicate 2, scRNAseq
- GSM8377064 Trisomic Day 10 hiPSC-CM, Replicate 1, scRNAseq
- GSM8377065 Trisomic Day 10 hiPSC-CM, Replicate 2, scRNAseq
- GSM8377066 Disomic Day 20 hiPSC-CM, Replicate 1, scRNAseq
- GSM8377067 Disomic Day 20 hiPSC-CM, Replicate 2, scRNAseq
- GSM8377068 Trisomic Day 20 hiPSC-CM, Replicate 1, scRNAseq
- GSM8377069 Trisomic Day 20 hiPSC-CM, Replicate 2, scRNAseq
- GSM8377070 Disomic dCas9-VPR CROPseq infected, Endogenous Library, scRNAseq
- GSM8377071 Disomic dCas9-VPR CROPseq infected, Amplicon Library, scRNAseq
- GSM8377072 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Endogenous Library, scRNAseq
- GSM8377073 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Endogenous Library, scRNAseq
- GSM8377074 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 3, Endogenous Library, scRNAseq
- GSM8377075 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 4, Endogenous Library, scRNAseq
- GSM8377076 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 5, Endogenous Library, scRNAseq
- GSM8377077 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 6, Endogenous Library, scRNAseq
- GSM8377078 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 7, Endogenous Library, scRNAseq
- GSM8377079 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 8, Endogenous Library, scRNAseq
- GSM8377080 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 9, Endogenous Library, scRNAseq
- GSM8377081 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 10, Endogenous Library, scRNAseq
- GSM8377082 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 11, Endogenous Library, scRNAseq
- GSM8377083 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 12, Endogenous Library, scRNAseq
- GSM8377084 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_1, scRNAseq
- GSM8377085 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_2, scRNAseq
- GSM8377086 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_3, scRNAseq
- GSM8377087 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_4, scRNAseq
- GSM8377088 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_5, scRNAseq
- GSM8377089 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_6, scRNAseq
- GSM8377090 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_7, scRNAseq
- GSM8377091 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_8, scRNAseq
- GSM8377092 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_9, scRNAseq
- GSM8377093 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 1, Amplicon Library_10, scRNAseq
- GSM8377094 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_1, scRNAseq
- GSM8377095 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_2, scRNAseq
- GSM8377096 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_3, scRNAseq
- GSM8377097 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_4, scRNAseq
- GSM8377098 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_5, scRNAseq
- GSM8377099 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_6, scRNAseq
- GSM8377100 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate 2, Amplicon Library_7, scRNAseq
- GSM8377101 Disomic dCas9-VPR CROPseq infected Day 20 Screen, Replicate21, Amplicon Library_8, scRNAseq
+ 44 more — browse all 84 samples with per-sample file links →
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Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.