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Effect of vitamin D and K on osteoclast differentiation of bone marrow derived macrophages induced by RANKL

GSE272401 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/16 Platform GPL24247
Summary
As essential nutrients for the human body, both vitamins D and K play important roles in bone health. However, little is known about the combined effect of vitamins D and K on osteoarthritis-related subchondral bone osteoclastogenesis. In this study, we aim to elucidate the underlying mechanisms of their synergistic effect in the RANKL-induced osteoclastogensis in vitro model.
Published in
Vitamins D and K jointly protect against osteoarthritis via regulating OSCAR during osteoclastogenesis
Zhao Y, Ou Q, Huang H et al. · Journal of orthopaedic translation 2025 · PMID 40476065 · doi:10.1016/j.jot.2025.03.018
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Also filed as BioProject PRJNA1136788 and SRA study SRP520388. Searching any of these in the dataset finder brings you back here.

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