Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, but Ang(1-7) is Not the Ligand
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is InsufficientPulmonary circulation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272518_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1137274 and SRA study SRP520719. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 5 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8403819 ACE70 ACE
- GSM8403820 ACE71 ACE
- GSM8403821 ACE168 ACE
- GSM8403822 ACE169 ACE
- GSM8403823 ACE259 ACE
- GSM8403824 ACE9432 ACE
- GSM8403825 ARC3815 ARC
- GSM8403826 ARC3816 ARC
- GSM8403827 ARC3817 ARC
- GSM8403828 ARD3821 ARD
- GSM8403829 ARD3822 ARD
- GSM8403830 ARD3823 ARD
- GSM8403831 ARV3826 ARV
- GSM8403832 ARV3827 ARV
- GSM8403833 ARV3828 ARV
- GSM8403834 AUS2079 AUS
- GSM8403835 AUS2080 AUS
- GSM8403836 AUS2082 AUS
- GSM8403837 AUS2084 AUS
- GSM8403838 AUS2085 AUS
- GSM8403839 AUS2086 AUS
- GSM8403840 AUS2090 AUS
- GSM8403841 AUS2091 AUS
- GSM8403842 AUS2092 AUS
- GSM8403843 AUS2096 AUS
- GSM8403844 AUS2097 AUS
- GSM8403845 AUS2098 AUS
- GSE333586 Formylpeptide Receptor Activation Attenuates Renovascular Remodeling in Neurogenic Hypertension (Left Ventricle) 26 samples shares activation, receptor
- GSE333587 Formylpeptide Receptor Activation Attenuates Renovascular Remodeling in Neurogenic Hypertension (Kidney) 19 samples shares activation, receptor
- GSE267270 Synthetic trimeric Interleukin-6 receptor complexes with a STAT3 phosphorylation dominated activation profile 16 samples shares activation, receptor
- GSE293372 Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors. [RNA-seq] 12 samples shares activation, receptor
- GSE198666 High-throughput sequencing for analysis of macropahges from old and young mice. 25 samples shares pah
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.