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Single cell RNA-sequencing of male and female dorsal root ganglia (DRG) following Bortezomib (BTZ) or vehicle (VEH) administration.

GSE275255 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/09/01 Platform GPL24247
Summary
Peripheral neuropathies are the most common neurodegenerative diseases affecting more than 20 million people in the USA alone. Chemotherapy, including treatment with the highly effective drug bortezomib (BTZ), is a frequent cause of peripheral neuropathy. We demonstrated recently that while some chemotherapeutics exert direct toxic effects on axons, BTZ leads to axon degeneration via signals from neuronal somata, which reside in the dorsal root ganglia (DRG). However, what these signals are and how they arise is unknown. To address this question, we treated mice intravenously with BTZ twice weekly for 8 weeks and determined the impact on DRG gene expression via single cell RNA-sequencing.
Published in
Targeting sex-specific DRG inflammation and neurofibrosis to prevent Bortezomib-induced neuropathy
Thomsen MB, Singh A, Thebeau CN et al. · Brain, behavior, and immunity 2025 · PMID 41027499 · doi:10.1016/j.bbi.2025.106124
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Direct links to NCBI, no account and no request form: the whole study as GSE275255_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1150120 and SRA study SRP527523. Searching any of these in the dataset finder brings you back here.

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